Abstract
The prognostic importance of baseline urines for cocaine was examined in a randomized, placebo-controlled, twelve-week clinical trial in 165 opioid- and cocaine-dependent patients who were treated with desipramine (DMI) in combination with buprenorphine (BUP) or methadone (Meth). Patients with a cocaine-positive urine at baseline (CU + ) had significantly fewer cocaine-free urines than those with a negative urine at baseline (CU-neg). The CU + patients showed no treatment effects of DMI compared to placebo, but the CU-neg patients showed a treatment effect of DMI. This DMI effect was significant in patients maintained on BUP but not on Meth.