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REGULAR ARTICLES

Systematic Assessment of Gamma Hydroxybutyrate (GHB) Effects During and After Acute Intoxication

, PharmD, , PhD, , PharmD, , PharmD, , MS & , MD
Pages 312-318 | Received 12 Oct 2007, Accepted 05 Dec 2007, Published online: 10 Jul 2009
 

Abstract

We adapted and tested a previously published questionnaire battery eliciting sensory and cognitive symptoms during (acute) and immediately after (post-acute) GHB intoxication. Studying 125 GHB users, we assessed the instrument's internal consistency using Cronbach's alpha (CA) and responsiveness to change comparing acute and post-acute symptoms. The final 14-item battery demonstrated good internal consistency (CA ≥ 0.85, both acute and post-acute). The median symptom score (possible range 0–64) was 30 (acute) and 6 (post-acute; difference p < 0.001). This modified substance-specific symptom battery, which is easily administered, demonstrated excellent performance characteristics. It can be used to study GHB and, potentially, related drugs of abuse.

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