Antiinsectan Activity of the Diterpene Sclareol and Analogs Against Fall Armyworm Spodoptera frugiperda

Samir A. Kouzi Medicinal and Natural Product Chemistry, School of Pharmacy, Northeast Louisiana University, Monroe, LA, 71209

Patrick F. Dowd Mycotoxin Research Unit, Agricultural Research Service, USDA, Peoria, IL, 61604

James D. McChesney Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS, 38677

Abstract

The natural diterpenoid sclareol (1) and ten of its analogs (2–11) were tested for their antiinsectan activity against the fall armyworm Spodoptera frugiperda. Two of the tested analogs, 2-keto-sclareol (3) and 8α, 13β-dihydroxy-labd-14-en-18-O-β-D-glucoside (10), showed significant activity.

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Antiinsectan Activity of the Diterpene Sclareol and Analogs Against Fall Armyworm Spodoptera frugiperda

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Antiinsectan Activity of the Diterpene Sclareol and Analogs Against Fall Armyworm Spodoptera frugiperda

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