Magnetic Bioactive SrFe₁₂O₁₉-SiO₂-CaO-Na₂O-P₂O₅ Glass-Ceramics for Hyperthermia Treatment of Bone Cancer

Abstract

The magnetic bioglass-ceramics were introduced for hyperthermia treatment of bone cancer. The aim of this work was to study the magnetic properties of ferrimagnetic glass-ceramics from SrFe₁₂O₁₉(SF)-SiO₂-CaO-Na₂O-P₂O₅ system by using the modified solid-state sintering method. The results showed that sodium calcium silicate (Na₄Ca₄Si₆O₁₈), strontium iron oxide (SrFe₁₂O₁₉) and iron oxide (Fe₂O₃) were precipitated in all samples. The saturation magnetization (M_s), remanence (M_r) and coercivity (H_c) increased by the addition of SF in the bioglass. The samples were soaked in simulated body fluid (SBF) for 14 days in order to investigate the bioactivity of the samples in vitro. The apatite layer was found on the surface of all bioglass-ceramics confirming their biocompatibility and it increased with increasing strontium ferrite content.

Keywords:

• 45S5 bioglass
• ferrimagnetic
• solid-state sintering
• biocompatibility

Acknowledgments

The authors would like to thank the Thailand Research Fund (TRF) and the National Research University (NRU), Office of Higher Education Commission and Faculty of Science, Chiang Mai University and Graduate School Chiang Mai University, Thailand, for financial support