Selective adsorption of chiral mandelic acid by molecularly imprinted poly(dimethylaminoethyl methacrylate) on surface of magnetic silica microspheres

ABSTRACT

A chiral mandelic acid (MA) molecularly imprinted microsphere with magnetism was designed in this paper. Firstly, a Fe₃O₄ core was synthesized by a simple and classical solvot hermal method. Then the SiO₂ shell was coated to the surface of Fe₃O₄ by a improved Stober method. Finally, dimethylaminoethyl methacrylate (DMAEMA) was graft-polymerized onto the surfaces of Fe₃O₄ @SiO₂ microspheres, and the molecular imprinting was conducted with S-MA as template molecule. The results of ultraviolet (UV) spectroscopy detection indicated that the magnetic chiral molecular imprinting had good selectivity for S-Mandelic acid and its enantiomer.

KEYWORDS:

• Mandelic acid
• chiral
• molecular imprinting
• magnetic microspheres

Funding

This work is financially supported by the National Natural Science Foundation of China (21375069, 21574072, 21675091, 21404065), the Natural Science Foundation for Distinguished Young Scientists of Shandong Province (JQ201403), the Taishan Young Scholar Program of Shandong Province (tsqn20161027), the Key Research and Development Project of Shandong Province (2016GGX102028, 2016GGX102039), the Project of Shandong Province Higher Educational Science and Technology Program (J15LC20), the Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry (20111568), the People's Livelihood Science and Technology Project of Qingdao (166257nsh), and the Postdoctoral Scientific Research Foundation of Qingdao.