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Integrated Ferroelectrics
An International Journal
Volume 206, 2020 - Issue 1: Proceedings of the Eighteenth China International Nanoscience and Techology Symposium (CINSTS19), Part I of V
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Articles

Multifunctional Carbon Dots Based Nanoparticles Coupling Optical and pH-Dependent Drug Release Properties as Drug Delivery Platforms

Hai-Lin CongInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, Affiliated Hospital of Qingdao University, College of Materials Science and Engineering, Qingdao University, Qingdao, China; ;State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, ChinaView further author information
,
Meng-Zhu WangInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, Affiliated Hospital of Qingdao University, College of Materials Science and Engineering, Qingdao University, Qingdao, China; View further author information
,
Yan-Hong XuInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, Affiliated Hospital of Qingdao University, College of Materials Science and Engineering, Qingdao University, Qingdao, China; View further author information
,
Song WangInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, Affiliated Hospital of Qingdao University, College of Materials Science and Engineering, Qingdao University, Qingdao, China; View further author information
,
You-Qing ShenInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, Affiliated Hospital of Qingdao University, College of Materials Science and Engineering, Qingdao University, Qingdao, China; View further author information
&
Bing YuInstitute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, Affiliated Hospital of Qingdao University, College of Materials Science and Engineering, Qingdao University, Qingdao, China; ;State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, ChinaCorrespondence[email protected]
View further author information
Pages 151-159 | Received 19 Jul 2019, Accepted 03 Feb 2020, Published online: 07 Apr 2020
 
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Abstract

A kind of red emissive carbon dots (R-CDs) that were synthesized by a hydrothermal method reacted with PEG polymer (mPEG-CHO) as nanocarriers (R-CD@mPEG-CHO). DOX was selected to be the model drug and loaded on the surface of R-CDs by physical adsorption. The mPEG-CHO polymer reacted with R-CDs and the benzoic acid-amine bond was formed through click reaction, which enabled the R-CD@mPEG-CHO to have pH responsive ability in tumor microenvironment and achieved controlled drug release. And PEGylation can suppress drug burst release in vitro. A potential multi-functional nanocarrier system was successfully built.

Additional information

Funding

This study was funded by the National Natural Science Foundation of China (21675091, 21874078), the Taishan Young Scholar Program of Shandong Province (tsqn20161027), the Major Science and Technology Innovation Project of Shandong Province (2018CXGC1407), the Key Research and Development Project of Shandong Province (2016GGX102028, 2016GGX102039, 2017GGX20111), the Innovation Leader Project of Qingdao (168325zhc), and the First Class Discipline Project of Shandong Province.

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