Alkyl Chain Modification is Used to Improve the Tumor Diagnosis and Treatment Performance of D-A-D Conjugated Small Molecules

Abstract

Malignant tumor is one of the most important causes of death in the world today. At present, the successful cure cases of tumor patients are mainly due to the timely treatment of tumors. Therefore, it has become one of the urgent problems for human beings to find tumors as soon as possible and how to completely eradicate them. The technology of simultaneous imaging and treatment through photoinitiation is a promising strategy to fight cancer. In the previous research, we developed a new small molecule p-QM2AF for photothermal therapy, but the low fluorescence efficiency (QY) in the NIR-II range made it necessary to modify it. In this paper, we obtained better imaging and photothermal conversion performance by grafting two 9- methylene nonadecanes onto the p-QM2AF sub-receptor.

Keywords:

• D-A-D type conjugated compounds
• second near-infrared
• fluorescence imaging
• photothermal conversion
• molecular modification

Additional information

Funding

This study was supported by the National Natural Science Foundation of China (21874078, 22074072, 22274083), the Innovation and Development Joint Fund of Natural Science Foundation of Shandong Province (ZR2022LZY022), the Science and Technology Planing Project of South District of Qingdao City (2022-4-005-YY), the Exploration project of the State Key Laboratory of Bio-Fibers and Eco-Textiles of Qingdao University (TSKT202101), and the High Level Discipline Project of Shandong Province.