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Journal of Environmental Science and Health, Part C
Environmental Carcinogenesis and Ecotoxicology Reviews
Volume 30, 2012 - Issue 2
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Original Articles

Assessment and Validation of US EPA's OncoLogic® Expert System and Analysis of Its Modulating Factors for Structural Alerts

ROMUALDO BENIGNI Istituto Superiore di Sanita’, Health and Environment Department, Rome, Italy
,
CECILIA BOSSA Istituto Superiore di Sanita’, Health and Environment Department, Rome, Italy
,
SILVIA ALIVERNINI Istituto Superiore di Sanita’, Health and Environment Department, Rome, Italy
&
MAURO COLAFRANCESCHI Istituto Superiore di Sanita’, Health and Environment Department, Rome, Italy
Pages 152-173 | Published online: 12 Jun 2012
 
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Abstract

OncoLogic® is a software program able to screen chemical compounds for toxicological effects. The software predicts the potential carcinogenicity of chemicals by applying rules of structure activity relationship (SAR) analysis. To validate the predictivity of OncoLogic® (Version 7.0), 123 compounds tested with the long-term carcinogenicity bioassay on rodents were extracted from the ISSCAN database and were analyzed. The concordance between the OncoLogic® SAR analysis and the bioassay results was high. To better understand the strength of the SAR science in OncoLogic®, we investigated the influence of a select group of modulating factors on the predictions by the structural alerts.

Acknowledgments

Work partially granted by: Italy-USA Cooperation Project “Systems effects of chemicals: evaluation of HighThroughPut profiling.”

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