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Journal of Environmental Science and Health, Part C
Environmental Carcinogenesis and Ecotoxicology Reviews
Volume 37, 2019 - Issue 3
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Articles

Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis

Dongying LiNational Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR, USAORCID Iconhttp://orcid.org/0000-0003-0721-2500
ORCID Icon,
William H. TollesonNational Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR, USACorrespondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0002-7682-3113
ORCID Icon,
Dianke YuNational Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR, USAORCID Iconhttp://orcid.org/0000-0002-2031-3683
ORCID Icon,
Si ChenNational Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR, USAORCID Iconhttp://orcid.org/0000-0002-8872-311X
ORCID Icon,
Lei GuoNational Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR, USA
,
Wenming XiaoNational Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR, USA
,
Weida TongNational Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR, USA
&
Baitang NingNational Center for Toxicological Research (NCTR), U.S. Food and Drug Administration (FDA), Jefferson, AR, USACorrespondence[email protected] [email protected]
 show all
Pages 180-214 | Published online: 15 Jul 2019
 
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Abstract

Environmental exposures to hazardous chemicals are associated with a variety of human diseases and disorders, including cancers. Phase I metabolic activation and detoxification reactions catalyzed by cytochrome P450 enzymes (CYPs) affect the toxicities of many xenobiotic compounds. Proper regulation of CYP expression influences their biological effects. Noncoding RNAs (ncRNAs) are involved in regulating CYP expression, and ncRNA expression is regulated in response to environmental chemicals. The mechanistic interactions between ncRNAs and CYPs associated with the toxicity and carcinogenicity of environmental chemicals are described in this review, focusing on microRNA-dependent CYP regulation. The role of long noncoding RNAs in regulating CYP expression is also presented and new avenues of research concerning this regulatory mechanism are described.

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