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Journal of Macromolecular Science, Part A
Pure and Applied Chemistry
Volume 43, 2006 - Issue 4-5
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Original Articles

A Novel Approach for Testing the Hixon‐Crowel Model For In Vitro Release of Vitamin B2 From Chitosan Coated Calcium Alginate Beads

S. K. Bajpai Polymer Research Laboratory, Department of Chemistry, Government Model Science College, Jabalpur, M.P., IndiaCorrespondence[email protected]
&
R. Tankhiwale Polymer Research Laboratory, Department of Chemistry, Government Model Science College, Jabalpur, M.P., India
Pages 621-626 | Received 01 Sep 2005, Accepted 01 Nov 2005, Published online: 07 Feb 2007
 
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Abstract

The dynamic release of a model drug (vitamin B2) from chitosan coated calcium alginate beads has been studied in the media of varying pH and the Hixon‐Crowel model has been applied to the experimental data, using a novel ‘curve area measurement’ (CAM) approach. The two release profiles, namely experimental and ideal, were found to be in close agreement except for the initial phase of the release process.

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