Quantitative Interpretation of the Deviation from ‘Zero-Order’ Kinetics for the Release of Cyanocobalamin from a Starch-Based Enzymatically Degradable Hydrogel

In vitro release of the model drug Cyanocobalamin, via enzymatic degradation of a starch based semi‐interpenetrating hydrogel network, has been studied in simulated intestinal fluid (SIF) of pH 6.8 at 37°C. The deviation of the formulation from ideal ‘zero–order’ kinetics was estimated by comparing the experimental ‘release rate vs. time’ profile with the ideal one and then expressing the deviation in terms of the difference in the curve areas between the two successive time points.

Keywords:

• hydrogel
• ‘zero–order’
• deviation
• colon
• enzymatic degradation