Examination of the Higuchi Model for the Release of Vitamin B₂ from Multilayered Calcium Alginate/Chitosan Beads in Varying pH Medium

The release of model drug vitamin B₂ from calcium alginate/chitosan multi‐layered beads has been studied in the media of varying pH (3 h in the medium of pH 1.0 and for the remaining time in pH 7.4) at 37°C. The quantitative deviation of experimental data from the Higuchi model has been interpretated by using a newly developed ‘curve area measurement’ (CAM) approach. The higher deviation in the initial phase has been explained on the basis of porous structure of beads due to the use of low molecular weight polymers in the preparation of beads.

Keywords:

• Higuchi
• alginate
• chitosan
• beads