Abstract
A novel series of N2O2 diazadioxa macrocyclic complexes [MLCl2] (M=Co2+, Ni2+ and Cu2+) have been synthesized with newly derived biologically active ligands (LI-LIV). These ligands were synthesized by the condensation of 1, 6-bis(2-formylphenyl)hexane and 3-subtituted-4-amino-5-hydrazino-1, 2, 4-triazole. The mode of bonding and overall geometry of the complexes have been inferred through IR, EPR, electronic spectral studies, conductivity, magnetic, thermal and electrochemical studies. All the complexes are soluble in DMF and DMSO and are non-electrolytes. All these complexes have been screened for their antibacterial (Escherichia coli, Staphylococus aureus, Salmonella typhi, Pseudomonas aeruginosa) and antifungal activities (Aspergillus niger, Aspergillus flavus and Cladosporium) by the MIC method. The DNA cleavage study was done by Agarose gel electrophoresis.
Keywords:
Acknowledgments
The authors are grateful to the Chairman, Department of Chemistry, Karnatak University, and Dharwad for the facilities. One of the authors (UVK) is grateful to the University Grant Commission, New Delhi for grant of Research Fellowship in Science for Meritorious Students.