Optical Study of Chitosan-Ofloxacin Complex for Biomedical Applications

Abstract

Chitosan ofloxacin complex was prepared in isopropyl alcohol under mild conditions. The ionic complexation between chitosan and ofloxacin was confirmed by Fourier transform infrared (FTIR), and nuclear magnetic resonance (NMR) spectroscopy. The crystallinity, thermal, surface morphology and optical properties were evaluated by X-ray diffraction (XRD) analysis, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), ultraviolet-visible (UV-Vis) spectroscopy, photoluminescence (PL) spectroscopy and second harmonic generation (SHG) studies, respectively. Absorption of the complex was high (10⁶cm⁻¹) with an optical band gap of 3.80 eV. The chitosan-ofloxacin complex may be considered as a novel optical material from biomedical application point of views. It may find applications as biosensors and environmentally sensitive membranes and artificial membranes.

Keywords:

• Chitosan
• ofloxacin
• complex
• optical property

Acknowledgements

This research was supported by the 2010 KU Brain Pool Program of Konkuk University, Seoul, South Korea. We are thankful to UGC, New Delhi, India for a research project to P. K. Dutta.