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Journal of Macromolecular Science, Part A
Pure and Applied Chemistry
Volume 50, 2013 - Issue 2
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Original Articles

Synthesis, Thermosensitive Gelation and Degradation Study of a Biodegradable Triblock Copolymer

Qin Wang Shandong Provincial Key Laboratory of Biomedical Polymers, Shandong Institute of Medical Instruments, Jinan, P. R. China
,
Chuandong Wang Shandong Provincial Key Laboratory of Biomedical Polymers, Shandong Institute of Medical Instruments, Jinan, P. R. China
,
Xu Du Shandong Provincial Key Laboratory of Biomedical Polymers, Shandong Institute of Medical Instruments, Jinan, P. R. China
,
Yang Liu Shandong Provincial Key Laboratory of Biomedical Polymers, Shandong Institute of Medical Instruments, Jinan, P. R. China
&
Lixia Ma Shandong Provincial Key Laboratory of Biomedical Polymers, Shandong Institute of Medical Instruments, Jinan, P. R. China
Pages 200-207 | Received 01 Jul 2012, Accepted 01 Aug 2012, Published online: 23 Jan 2013
 
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Abstract

A series of biodegradable triblock copolymers PLA-PEG-PLA were synthesized by ring-opening polymerization of D,L-lactide using PEG as initiator. The structures and molecular weights of the triblock copolymers were characterized by1H-NMR and GPC.Their thermal properties were tested by DSC. The thermosensitive gelation behaviors and hydrolytic degradation were investigated. Sol-gel transition was observed with proper LA/EG ratios from 2.23 to 2.57. Besides, the sol-gel transition temperature has a close relation with the concentration and molecular weight of the triblock copolymers. The hydrolytic degradation experiment indicates the copolymers with lower LA/EG ratios degrade faster, and the degradation probably occurred at the PLA block at random.

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