Extended release of Gliclazide from highly stabilized calcium alginate/poly(acrylamide) beads for diabetes management

ABSTRACT

In the present work, stability of calcium alginate beads has been remarkably improved by a novel strategy which consists of in situ formation of poly (acrylamide) within the calcium ions cross-linked sodium alginate beads. The resulting beads have been found to be stable for more than 48 h, in the physiological fluid (PF) of pH 7.4, while the plain alginate beads disintegrated within a couple of hours. The release of the anti-diabetic drug Gliclazide (Glz) from the beads was investigated under physiological conditions. The enhanced stability and prolonged release was also confirmed by an in vivo study on Albino Wistar rats.

KEYWORDS:

• Alginate
• beads
• Gliclazide release
• in situ polymerization
• physiological fluid
• water uptake

Acknowledgments

The authors are thankful to Dr. O.P. Sharma, Head of the Department of Chemistry, Govt. Model Science College Jabalpur, M. P., for his kind and unconditional support. This research received no specific grant in the public, commercial or not-for-profit sector. The authors are also thankful to ISER Bhopal for the analysis of samples.