Molecularly imprinted cryogel as a pH-responsive delivery system for doxorubicin

ABSTRACT

In this study, implantable and degradable molecularly imprinted cryogel was prepared for pH-responsive delivery of doxorubicin. Cryogel discs were synthesized using amino acid-based functional monomer with HEMA and gelatin. The molecularly imprinted discs were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, degradation and swelling tests. In vitro delivery experiments were carried out in order to examine the effects of medium pH and drug content. The degree of degradation of composite cryogels was found to be 83.45±1.86% after 56 days. The release profiles of DOX from molecularly imprinted cryogel discs exhibit a biphasic delivery. It was observed that an initial burst release step from 0 to 12 h was followed by a slower and sustained release. Release rate of DOX from cryogel discs increased in more acidic conditions. Kinetic studies showed that a combination of diffusion and erosion control is mainly responsible from the general release behaviors of molecularly imprinted cryogel discs.

KEYWORDS:

• Cryogels
• doxorubicin delivery
• molecular imprinting
• pH responsive

Funding

Kemal Çetin thanks The Scientific and Technological Research Council of Turkey (TUBITAK) for the support by “TUBITAK-BIDEB 2211-National Ph.D Scholarship Programme.”