Synthesis of EDTA core dendrimers through a consecutive esterification-CuAAC process

ABSTRACT

A novel class of thermostable G0 and G1-dendrimers was synthesized from the coupling of both propargyl and azido esters derived from EDTA through copper catalyzed azide-alkyne cycloaddition. The branching and size in these compounds were controlled by a simple azide-alkyne group position change in the CuAAC reaction in conjunction with the use of 1,3-diazido-propan-2-ol as a polyfunctional compound.

KEYWORDS:

• dendrimer
• EDTA
• ester
• click chemistry

Acknowledgments

Financial support from CONACYT (Project No. 135053) is gratefully acknowledged. The authors would like to thank Signa S.A. de C. V., N. Zavala, A. Nuñez and L. Triana, for the technical support.