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Abstract
Polymeric carrier for combination therapy of tuberculosis, namely low molecular weight reactive copolymer of acrylic acid with 2-hydroxyethyl methacrylate (AA-co-2-HEMA) with two types of functional groups along the chain has been synthesized. Characteristic features of radical copolymerization were studied and the relationships between the synthesis conditions and the composition, microstructure, and molecular characteristics of the copolymers were established, that is of fundamental interest. The behavior of copolymer macromolecules in aqueous salt solutions was analyzed. A tuberculostatically active derivative of AA-co-2-HEMA containing the amikacin antibiotic and the monofluoroquinolone ciprofloxacin was synthesized. The target multiunit copolymer containing two tuberculostatics with different effect against tuberculosis mycobacterium exhibits high anti-tuberculosis activity. It is characterized by a gradual release of the drugs from the polymer form and is very promising for use in combination therapy of tuberculosis.
GRAPHICAL ABSTRACT
Acknowledgements
The authors are grateful to Prof. Dr. V. V. Tets for conducting microbiological studies of ciprofloxacin, amikacin and their polymeric derivatives and Dr. A. I. Amirova for help in hydrodynamic measurements.
Disclosure statement
The authors report there are no competing interests to declare.
Data availability statement
The data that support the findings of this study are available from the corresponding author, E.T., upon reasonable request.