Recent Advances in Synthetic Membrane Transporters

Abstract

It is 25 years since the first report of a synthetic ion channel transporter. Today, dozens of molecular and supramolecular designs have been developed to facilitate ion and small molecule transport across a bilayer membrane. Presented here is a concise summary of the advances made over the past four years. The transporters are grouped into three mechanistic classes: mobile carrier, monomeric channel, and self-assembled pore. Common building blocks are crown ethers, steroids, cyclodextrins, peptides, curcubiturils, and calixarenes. The eventual goal is to produce functional supramolecular devices such as sensors, enzyme assays, and lead candidates for pharmaceutical development.

Keywords:

• Membrane transport
• Ionosphere
• Ion channel
• Mobile carrier
• Membrane pore
• Self-assembly
• Phospholipid bilayer

Acknowledgements

We are grateful for funding support from the NIH (USA).