Abstract
Two novel DNA-intercalating binuclear polymers, [Co2(nipa)(Hbims)2] (1) and [Cu(nipa)(H2O)]·10H2O (2) with nipa and bims (H2nipa = 5-nitroisophthalic acid, H2bims = bis(2-benzimidazolylmethyl) sulfide), have been synthesised by hydrothermal methods and characterised by elemental analysis, IR, single-crystal X-ray diffraction, UV–vis and fluorescent spectrum. 5-Nitroisophthalate ligand adopts μ2- and μ4-bridging coordination fashion and bims exists as bridging-mode in complexes. The DNA-binding interactions and their in vitro cytotoxicities towards four selected tumour cell lines have been investigated. Both of them bind to DNA by intercalative mode, presenting the high DNA-binding affinity. They possess the highest inhibitory rate on A549 and show good inhibition activity.
![](/cms/asset/731960ca-05d5-4568-abba-6dd3516c9d5f/gsch_a_1087524_uf0001_oc.jpg)
Acknowledgement
We acknowledge financial support by the National Natural Science Foundation of China [grant number 51463023] and [grant number 21461028], Guangxi Key Laboratory of Farm Products Processing (Cultivation Base) and Guangxi Colleges and Universities Program of Innovative Research Team and Outstanding Talent.
Disclosure statement
No potential conflict of interest was reported by the authors.