The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation

Abstract

Therapeutic peptides are conventionally administered via subcutaneous injection. Chitosan-based nanoparticles are gaining increased attention for their ability to serve as a carrier for oral delivery of peptides and vaccination. They offered superior biocompatibiltiy, controlled drug release profile and facilitated gastrointestinal (GI) absorption. The encapsulated peptides can withstand enzymatic degradation and various pH. Chitosan-based nanoparticles can also be modified by ligand conjugation to the surface of nanoparticle for transcellular absorption and specific-targeted delivery of macromolecules to the tissue of interest. Current research suggests that chitosan-based nanoparticles can deliver therapeutic peptide for the treatment of several medical conditions such as diabetes, bacterial infection and cancer. This review summarises the role of chitosan in oral nanoparticle delivery and identifies the clinical application of peptide-loaded chitosan-based nanoparticles.

Keywords:

• Chitosan
• nanoparticle
• protein
• peptide
• oral

Acknowledgements

This article was not prepared with a specific grant from any funding agency in the public, commercial, or not-for-profit sectors. CRD is supported by a Curtin Academic50 scheme.

Disclosure statement

The authors declare that they have no conflicts of interest to disclose.