Advanced search
Publication Cover
Journal of Drug Targeting Volume 27, 2019 - Issue 2
Submit an article Journal homepage
217
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Patterns of sensitivity to a panel of drugs are highly individualised for undifferentiated/unclassified soft tissue sarcoma (USTS) in patient-derived orthotopic xenograft (PDOX) nude-mouse models

Kei KawaguchiAntiCancer, Inc, San Diego, CA, USA; ;Department of Surgery, University of California, San Diego, CA, USA; ;Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan;
,
Kentaro IgarashiAntiCancer, Inc, San Diego, CA, USA; ;Department of Surgery, University of California, San Diego, CA, USA;
,
Kentaro MiyakeAntiCancer, Inc, San Diego, CA, USA; ;Department of Surgery, University of California, San Diego, CA, USA;
,
Tasuku KiyunaAntiCancer, Inc, San Diego, CA, USA; ;Department of Surgery, University of California, San Diego, CA, USA;
,
Masuyo MiyakeAntiCancer, Inc, San Diego, CA, USA; ;Department of Surgery, University of California, San Diego, CA, USA;
,
Arun S. SinghDivision of Hematology-Oncology, University of California, Los Angeles, CA, USA;
,
Bartosz ChmielowskiDivision of Hematology-Oncology, University of California, Los Angeles, CA, USA; ORCID Iconhttp://orcid.org/0000-0002-2374-3320
ORCID Icon,
Scott D. NelsonDepartment of Pathology, University of California, Los Angeles, CA, USA;
,
Tara A. RussellDivision of Surgical Oncology, University of California, Los Angeles, CA, USA; ORCID Iconhttp://orcid.org/0000-0002-3912-3601
ORCID Icon,
Sarah M. DryDepartment of Pathology, University of California, Los Angeles, CA, USA;
,
Yunfeng LiDepartment of Pathology, University of California, Los Angeles, CA, USA;
,
Michiaki UnnoDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan;
,
Shree Ram SinghBasic Research Laboratory, National Cancer Institute, Frederick, MD, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-6545-583X
ORCID Icon,
Fritz C. EilberDivision of Surgical Oncology, University of California, Los Angeles, CA, USA; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3336-9333
ORCID Icon &
Robert M. HoffmanAntiCancer, Inc, San Diego, CA, USA; ;Department of Surgery, University of California, San Diego, CA, USA; Correspondence[email protected]
 show all
Pages 211-216 | Received 17 Feb 2018, Accepted 09 Jul 2018, Published online: 23 Aug 2018
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

Undifferentiated/unclassified soft tissue sarcoma (USTS) is a recalcitrant disease; therefore, precise individualised therapy is needed. Toward this goal, we previously established patient-derived orthotopic xenograft (PDOX) models of USTS in nude mice. Here, we determined the extent of uniqueness of drug response in a panel on USTS PDOX models from 5 different patients. We previously showed that 3 of the 5 patients were resistant to doxorubicin (DOX) despite DOX being first-line therapy. Two weeks after orthotopic tumour implantation, PDOX mouse models were randomised into five groups: untreated control, DOX, gem-citabine/docetaxel (GEM/DOC), pazopanib (PAZ), temozolomide (TEM). Three PDOX cases were completely resistant to DOX. TEM had high efficacy for 4 USTS PDOX models, including DOX-resistant cases. GEM/DOC and PAZ were effective in three USTS PDOX. One case was completely resistant to TEM. Two cases were completely resistant to PAZ. The results showed the drug sensitivity pattern for each USTS PDOX was highly individualised and that at least one effective drug could be found for each. The PDOX model could be effective in precise individualised drug sensitivity testing which is especially important for heterogeneous cancers such as USTS, and can give the patient a greater chance to be treated with an effective drug.

Acknowledgements

This manuscript is dedicated to the memory of Dr. A.R. Moossa and Dr. Sun Lee.

Disclosure statement

No potential conflict of interest was reported by the authors.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 767.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.