SIRT1: a potential tumour biomarker and therapeutic target

Abstract

SIRT1, which is highly homologous to yeast silent information regulator 2, has recently garnered tremendous attention because of its various regulatory effects in several pathological conditions. Numerous studies have found that SIRT1 is highly expressed in a broad range of tumours compared with the paracancerous tissue. However, the role of SIRT1 in malignancies has yet to be systematically elucidated, and its use as a promising biomarker or therapeutic target for tumours has not been well-reported. Herein, we focus on the roles of SIRT1 in cancers and summarise the potential use of SIRT1 as a promising tumour biomarker or therapeutic target.

Keywords::

• SIRT1; tumour diagnosis; tumour prognosis; tumour biomarker; therapeutic target

Disclosure statement

The authors declared no commercial, proprietary or financial interests in the products or companies described in this article.

Additional information

Funding

This work was supported by the Science and Technology Planning Project of Shenzhen of China [JCYJ20170412140904406] and the Innovation Foundation for Doctoral Dissertation of Northwestern Polytechnical University [CX201969].