Biomedical application of chondroitin sulfate with nanoparticles in drug delivery systems: systematic review

Abstract

Chondroitin sulphate captured an increasing amount of attention in the field of drug delivery systems. Nanoparticles and chondroitin sulphate were combined in different ways to form effective target nanocarriers. The study aimed to evaluate the biomedical application of chondroitin sulphate with nanoparticles in drug delivery systems. We searched PubMed, Google Scholar, and MEDLINE for studies that included data for the application of chondroitin sulphate and nanoparticles in targeting drug delivery published in English up to 25 February 2020. OHAT (Office of Health Assessment and Translation) Risk-of-Bias Tool was used to assessing the quality and risk of bias of each study. We performed a qualitative synthesis of findings from included studies. The toxicity of developed drugs has been evaluated using cell viability percentage and 50% inhibitory concentration of drugs. Twenty original articles reported the application of chondroitin sulphate on drug delivery systems were selected. Drug loading and encapsulation efficiency were from 2% to 16.1% and from 39.50% to 93.97%, respectively. The drug release was fast at start time and followed by a slow and sustain released stage. The risk of bias was rated as high in two out of twenty studies. Most of the studies presented baseline characteristics and outcomes appropriately.

Keywords:

• Chondroitin sulphate
• nanoparticles
• nanocarriers
• cellular release
• cellular uptake
• cytotoxicity
• drug delivery systems

Acknowledgments

The authors thank Leilei Pei School of Public Health, Xi’an Jiaotong University for his support and cooperation in the draft of this article.

Disclosure statement

The authors declare that they have no conflict of interest.

Data availability statement

All data utilised are publicly available.

Additional information

Funding

This study was supported by Shenzhen Science and Technology Project [JCYJ20170816100755047] and the National Natural Science Foundation of China [81872567]. The study sponsors did not involve in the study design, data collection, analysis or interpretation, or in the writing of the manuscript, neither did they affect the decision to submit the manuscript for publication.