https://orcid.org/0000-0002-6796-0204
![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Metabolic syndromes are a group of metabolic disorders for which the molecular mechanisms are still unclear. An increasing number of studies have implicated metabolic syndrome in the association with inflammation. Currently, lipsomes is known to improve nanoparticle hydrophobicity. Meanwhile, in drug delivery systems the application of cholesterol, which is commonly used to stabilise liposomal structures, has essentially no pharmacological effect on liposomes. Herein, we developed an ‘anti-inflammatory liposome’ (Phy-Lip) to effectively handle these challenges via employing Phytosterol instead of cholesterol. Different with the conventional liposomes, Phy-Lip is a much more brilliant nanoparticle with anti-inflammatory functions. In Phy-Lip, cholesterol was substituted by Phy, which works as membrane stabiliser, anti-inflammatory adjuvant at the same time. The experimental results show that Phy-Lip has a strong anti-inflammatory effect, and improves Metabolic syndromes. This study aims to provide a way to solve the challenge.
Acknowledgments
Gratefully acknowledges the assistance of the medicinal chemistry laboratory with the molecular docking technique.
Data availability
The study data are available from the corresponding author.
Disclosure statement
No potential conflict of interest was reported by the author(s).
CRediT authorship contribution statement
Daquan Chen: Conceptualisation. Qiang Chen: Methodology, Writing – original draft. Chunjing Guo: Software. Min Cao, Zhongxin Liu, Wenxin Wang: Data curation. Dandan Zhang, Hongxu Geng, Ningning Diao: Visualisation. Daquan Chen: Writing – review & editing.