Chemical structure determines target organ carcinogenesis in rats

Abstract

SAR models were developed for 12 rat tumour sites using data derived from the Carcinogenic Potency Database. Essentially, the models fall into two categories: Target Site Carcinogen–Non-Carcinogen (TSC-NC) and Target Site Carcinogen–Non-Target Site Carcinogen (TSC-NTSC). The TSC-NC models were composed of active chemicals that were carcinogenic to a specific target site and inactive ones that were whole animal non-carcinogens. On the other hand, the TSC-NTSC models used an inactive category also composed of carcinogens but to any/all other sites but the target site. Leave one out (LOO) validations produced an overall average concordance value for all 12 models of 0.77 for the TSC-NC models and 0.73 for the TSC-NTSC models. Overall, these findings suggest that while the TSC-NC models are able to distinguish between carcinogens and non-carcinogens, the TSC-NTSC models are identifying structural attributes that associate carcinogens to specific tumour sites. Since the TSC-NTSC models are composed of active and inactive compounds that are genotoxic and non-genotoxic carcinogens, the TSC-NTSC models may be capable of deciphering non-genotoxic mechanisms of carcinogenesis. Together, models of this type may also prove useful in anticancer drug development since they essentially contain chemical moieties that target a specific tumour site.

Keywords:

• structure-activity relationship
• cancer
• organ-specific carcinogens
• genotoxic carcinogens
• non-genotoxic carcinogens

Acknowledgments

This research was supported by the National Institutes of Health (P20 RR018733) and the Department of Defense Breast Cancer Research Program (DAMD17-01-0376). Views and opinions of, and endorsements by, the author(s) do not reflect those of the US Army or the Department of Defense.