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SAR and QSAR in Environmental Research Volume 35, 2024 - Issue 2
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Research Article

Steroidal hydrazones as antimicrobial agents: biological evaluation and molecular docking studies

M. Merlania TSMU I, Kutateladze Institute of Pharmacochemistry, Tbilisi, GeorgiaView further author information
,
N. Nadaraiaa TSMU I, Kutateladze Institute of Pharmacochemistry, Tbilisi, GeorgiaView further author information
,
N. Barbakadzea TSMU I, Kutateladze Institute of Pharmacochemistry, Tbilisi, GeorgiaView further author information
,
L. Amiranashvilia TSMU I, Kutateladze Institute of Pharmacochemistry, Tbilisi, GeorgiaView further author information
,
M. Kakhabrishvilia TSMU I, Kutateladze Institute of Pharmacochemistry, Tbilisi, GeorgiaView further author information
,
A. Petroub School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, GreeceORCID Iconhttps://orcid.org/0000-0001-8587-2710View further author information
ORCID Icon,
T. Carevićc Department of Plant Physiology, Institute for Biological Research “Siniša Stanković” - National Institute of Republic of Serbia, University of Belgrade, Belgrade, SerbiaView further author information
,
J. Glamočlijac Department of Plant Physiology, Institute for Biological Research “Siniša Stanković” - National Institute of Republic of Serbia, University of Belgrade, Belgrade, SerbiaView further author information
&
A. Geronikakib School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, GreeceCorrespondence[email protected]
View further author information
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Pages 137-155 | Received 28 Nov 2023, Accepted 17 Jan 2024, Published online: 05 Feb 2024
 
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ABSTRACT

Most of pharmaceutical agents display several or even many biological activities. It is obvious that testing even one compound for thousands of biological activities is a practically not reasonable task. Therefore, computer-aided prediction is the method of choice for the selection of the most promising bioassays for particular compounds. Using PASS Online software, we determined the probable antimicrobial activity of the 31 steroid derivatives. Experimental testing of the antimicrobial activity of the tested compounds by microdilution method confirmed the computational predictions. Furthermore, P. aeruginosa and C. albicans biofilm formation was investigated. Compound 11 showed a biofilm reduction by 42.26% at the MIC of the tested compound. The percentages are lower than ketoconazole, but very close to its activity.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported that there is no funding associated with the work featured in this article.

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