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Hypertension in Pregnancy Volume 26, 2007 - Issue 1
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Original

Maternal Leptin Concentrations are Similar in African Americans and Caucasians in Normal Pregnancy, Preeclampsia and Small-for-Gestational-Age Infants

Laura D. Jenkins Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Departments of Family Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USACorrespondence[email protected]
,
Robert W. Powers Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Obstetrics & Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
,
Mary Adotey Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
,
Marcia J. Gallaher Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
,
Nina Markovic Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
,
Roberta B. Ness Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
&
James M. Roberts Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Obstetrics & Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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Pages 101-109 | Published online: 07 Jul 2009
 
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Abstract

Leptin concentrations were measured in African American women in order to assess leptin's role in the increased frequency and severity of preeclampsia. In addition, leptin concentrations were measured in women who delivered small-for-gestational-age (SGA) infants. A case-control study of African American and Caucasian women with normal pregnancies, preeclampsia, or SGA infants was done. Plasma leptin was quantitated by radio-immunoassay. The previously recognized pattern of increased leptin concentrations in preeclampsia was replicated. Leptin concentrations did not differ by race in any diagnostic category, and concentrations in women with SGA infants were not higher than those in healthy women. Differences in the frequency and severity of preeclampsia in African Americans cannot be explained by higher leptin concentrations.

Notes

*Funded in part by National Institutes of Health grants NIH-5MO1-RR00056 and NIH-PO1-HD30367.

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