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Hypertension in Pregnancy Volume 26, 2007 - Issue 4
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Perinatal Changes of Circulating N-Terminal Pro B-Type Natriuretic Peptide (NT-proBNP) in Normal and Intrauterine-Growth-Restricted Pregnancies

Nicoletta Iacovidou Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece
, MD,
Despina D. Briana Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece
, MD,
Maria Boutsikou Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece
, MD,
Demetrios Gourgiotis Research Laboratories, Second Department of Paediatrics, Athens University Medical School, Athens, Greece
, PhD,
Stavroula Baka Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece
, MD,
Venetia-Maria Vraila Research Laboratories, Second Department of Paediatrics, Athens University Medical School, Athens, Greece
, MD,
Demetrios Hassiakos Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece
, MD &
Ariadne Malamitsi-Puchner Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, GreeceCorrespondence[email protected] [email protected]
, MD show all
Pages 463-471 | Published online: 07 Jul 2009
 
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Abstract

Objective: To investigate changes in NT-proBNP in intrauterine-growth-restricted (IUGR) and appropriate-for-gestational-age (AGA) pregnancies. Methods: NT-proBNP levels were measured in 40 mothers (MS), umbilical cords (UC), and their 20 IUGR/ 20 AGA neonates on day 1 (N1) and day 4 (N4). Results: UC, N1, and N4 NT-proBNP was lower in IUGR pregnancies (p ≤ 0.049). In both groups, NT-proBNP levels were similar in MS and higher in N1 (p ≤ 0.001). In AGA, MS NT-proBNP correlated positively with UC. Conclusions: Fetal and neonatal NT-proBNP levels are lower in IUGR compared with AGA, probably due to blood flow redistribution in IUGR and NT-proBNP placental transport in AGA. NT-proBNP levels peak on N1.

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