Does Uric Acid Provide Information About Maternal Condition and Fetal Outcome in Pregnant Women with Hypertension?

Abstract

Objective: To evaluate associations between maternal serum uric acid (UA) levels, maternal status, and fetal outcome. Methods: Maternal UA, urinary protein-creatinine ratio (P/C), blood pressure (BP), gestational age at delivery, and birth weight were evaluated in hypertensive pregnant women (n = 58). These were divided into two groups: high UA (≥357 μmol/L) or normal UA (<357 μmol/L). Results: Maternal diastolic BP and P/C ratio were higher in pregnant women with elevated UA levels. Systolic BP, gestational age and birth weight were not significantly different. Conclusion. UA equal or above 357 μmol/L in pregnant hypertensive women was associated with proteinuria and diastolic BP, but not with fetal outcome.

Keywords:

• Hyperuricemia
• Pregnancy induced hypertension
• Proteinuria
• Preeclampsia
• Prematurity

Notes

Sources of Financial Support: this study was supported by CNPq-CAPES-FAPERGS-MS, the Pontificia Universidade Católica do Rio Grande do Sul and by the Gynecology and Obstetric Division at Hospital São Lucas, Porto Alegre, Brazil.