The C825T Polymorphism in the G-protein Beta 3 Subunit Gene in Chinese Patients with Preeclampsia

Abstract

Objectives: The objective of the study was to investigate the relationship of a C825T polymorphism of the gene encoding the G protein β3 subunit with preeclampsia in a South-West Chinese population. Results: In the case-control study which included 221 preeclamptic case subjects and 277 normal control subjects the allele frequency of 825C→T in the GNB3 gene was 47.29% in patients with preeclampsia and 49.28% in the control group. Furthermore, there was no significant association between the polymorphism and blood pressure levels in the case or control group. However, it showed that the TT homozygotes (n = 39) in obese patients had higher diastolic blood pressure levels than CC homozygotes (n = 47) or CT heterozygotes (n = 84) during pregnancy (p < 0.05). Conclusion: Our work does not provide evidence in favor of GNB3 C825T being a candidate gene for conferring genetic susceptibility to preeclampsia in a South West Chinese population.

Keywords:

• Pregnancy induced hypertension
• Preeclampsia
• G-protein beta 3 subunit gene; Polymorphism