Correlation of 2-Hour and 4-Hour Urinary Proteins with 24-Hours Proteinuria in Hospitalized Patients with Preeclampsia

Abstract

Objective: To determine whether 2-hour and 4-hour urinary proteins correlate with 24-hour proteinuria in patients with preeclampsia. Study design: Protein estimation was done from 2-hour, 4-hour, and 24-hour urine samples in 50 women with preeclampsia and the results were compared. Results: Statistical analysis demonstrated no significant difference in the mean protein excretion when comparing the 2-hour values with the 24-hour and further comparing 4-hour values with the 24-hour value. The values of 2-hour and 4-hour urine proteins in total volume (TV) correlated well with 24-hour value for mild & severe disease (p < 0.001). Amount of the protein excretion in 2-hour and 4-hour samples predicted mild preeclampsia with positive predictive value of 100% and negative predictive value (NPV) of 80%. NPV of both the samples for severe preeclampsia was 100%. Conclusion: 2-hour and 4-hour proteinuria can be used for initial assessment of preeclampsia thereby avoiding the inconvenience and delay in treatment.

Keywords:

• Preeclampsia
• Proteinuria
• 2-hour and 4-hour urinary protein estimation
• Total volume (TV)