Association between hypertensive disorders complicating pregnancy and risk of placenta accreta: a meta-analysis and systematic review

ABSTRACT

Objective: Previous studies have reported a positive association between hypertensive disorders complicating pregnancy and placenta accreta. However, whether hypertensive disorders complicating pregnancy associated with placenta accreta is still not clear. The objective was to systematically review the literature to determine a possible association between hypertensive disorders complicating pregnancy and placenta accreta. Methods: A systematic search of PubMed database, the Cochrane Library, Willy Online Library, and ScienceDirect database through 1st December 2015, was conducted. Two authors independently assessed data extraction and quality of the studies using the Newcastle-Ottawa Scale. Assessment of heterogeneity and analysis of data were operated by Review Manager 5.3.0. Results: Three studies involving 4174 patients who developed hypertensive disorders complicating pregnancy of a total of 38,004 pregnant women were selected. The result of our meta-analysis revealed that pregnancy induced hypertension was significantly associated with a reduction of placenta accreta (OR = 0.50, 95% CI: 0.30–0.82; heterogeneity: I² = 13%, p = 0.32). Conclusions: Our meta-analysis demonstrated that the risk of placenta accreta is reduced in women with hypertensive disorders complicating pregnancy. Further well-designed studies are warranted to testify the result and explored any potential mechanism association between hypertensive disorders complicating pregnancy and placenta accreta.

KEYWORDS:

• Hypertensive disorders
• placenta accreta
• meta-analysis

Acknowledgments

We appreciate the efforts of all the researchers whose articles were included in this study.

Additional information

Notes on contributors

Zhengping Liu

ZL participated in the design and coordination of the study. WW conceived the study and drafted the manuscript. JW and SW searched for the studies, collected, and analyzed the data. DF participated in the design of this study and edited the manuscript. YL and YH did the data management and analyzed the data. All authors read and approved the final manuscript.