New insight into the role of long non-coding RNAs in the pathogenesis of preeclampsia

ABSTRACT

Objective:Dysregulation of lncRNAs and the absence of coordination between them could affect the normal placentation, uteroplacental circulation, and endothelial cell function. All these misfunctions can finally lead to preeclampsia.

Methods: In the present review, we discuss current literature (till May 2018) about lncRNAs expression and function in the placenta, trophoblast cells, and decidua.

Results and conclusion: It is explained how altered expression of the lncRNAs and abnormal regulation of them affect the risk of preeclampsia. However, the interaction between various lncRNAs and coordinate regulation of them in health and failure of such coordinative mechanisms in diseases such as preeclampsia need to be elucidated.

KEYWORDS:

• LncRNA
• preeclampsia
• placenta
• cell signaling
• angiogenesis
• apoptosis

Disclosure statement

The authors declare that they have no conflict of interest.