The importance of proteinuria in preeclampsia and its predictive role in maternal and neonatal outcomes

ABSTRACT

Objective: To evaluate impact of 24-h proteinuria level in preeclampsia on maternal/perinatal outcomes.

Methods: Singleton pregnancies with preeclampsia delivered after 24 weeks of gestation were included. Patients were divided into mild (0.3 to <2 g) (n=72), severe (2 to <5 g) (n=30), and massive (≥5 g) (n=24) proteinuria groups, and cut-off values of 24-h proteinuria for composite adverse maternal and neonatal outcomes were calculated.

Results: Twenty-four hour  proteinuria level cut-offs for composite adverse outcomes were 3275 mg (72.2% sensitivity, 85.6% specificity) and 2395 mg (72.7% sensitivity, 78% specificity) respectively.

Conclusion: Severe and massive proteinuria were related to poor maternal, perinatal, and neonatal outcomes.

KEYWORDS:

• Pregnancy
• preeclampsia
• proteinuria

Acknowledgments

Special thanks to all the health-care staff of our institution for their respectable effort for the patients.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.