Role of vitamin D in influencing angiogenesis in preeclampsia

ABSTRACT

Objective: Vitamin D plays a key role during pregnancy and is involved in implantation and maintenance of pregnancy. Its deficiency is associated with pregnancy complications like preeclampsia, characterized by abnormal angiogenesis.Method: The current article summarises studies examining the role of vitamin D in pregnancy, with special emphasis on preeclampsia.Results and conclusion: An imbalance in pro- and anti-angiogenic factors is reported in women with preeclampsia. Cell culture studies have demonstrated that vitamin D can influence the process of angiogenesis. However, the role of maternal vitamin D in influencing placental angiogenesis in preeclampsia is unclear and needs to be explored.

KEYWORDS:

• Vitamin D
• angiogenesis
• preeclampsia
• VEGF
• PI3/AKT
• one carbon cycle

Acknowledgments

The author JN is the recipient of the ‘Junior Research Fellowship’ from the Council of Scientific and Industrial Research (CSIR), Government of India.

Declaration

The final version of the manuscript being submitted is seen and approved by all authors and the article hasn’t received prior publication and isn’t under consideration for publication elsewhere.

Disclosure statement

No potential conflict of interest was reported by the authors.