Negative association between serum adropin and hypertensive disorders complicating pregnancy

ABSTRACT

Objective: Study the association of adropin and hypertensive disorders complicating pregnancy (HDCP).

Methods: Patients with HDCP were matched with normotensive women (47 pairs). Adropin concentrations were detected by enzyme-linked immunosorbent assay.

Results: Compared with the controls, the serum adropin levels were lower in the HDCP group (P < 0.001) and in HDCP subgroups (gestational hypertension, mild preeclampisa, and severe preeclampsia, term, preterm, early onset, and late onset) (all P < 0.05). After adjustment for confounders, adropin remained negatively associated with HDCP (P = 0.027).

Conclusion: Lower adropin concentration is significantly associated with HDCP, suggesting that higher or normal adropin levels may be protective against HDCP.

KEYWORDS:

• Adropin
• hypertension
• pregnancy
• hypertensive disorders complicating pregnancy
• pre-eclampsia

Acknowledgments

The authors wish to thank Dr. William Ba-Thein, a professor of Shantou University Medical College, for his constructive comments on this paper. The authors also thank all the health-care workers of the obstetrical and gynecological department of the first affiliated hospital of Shantou University for their assistance. This work was supported by the National Natural Science Foundation of China under Grant (NO. 81473063).

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [81473063].