Pre-existing medical disorders as risk factors for preeclampsia: an exploratory case-control study

ABSTRACT

Objective: We sought to explore pre-existing medical disorders as risk factors for preeclampsia as thoroughly as possible.

Methods: A case-control design. A group of 1,652 patients were identified as the preeclampsia group, and another randomly selected 4,500 patients were identified as the non-preeclampsia group.

Results: Mature ovarian teratoma (adjusted odds ratio [OR] 7.69, 95% CI 1.58–37.53), uterine fibroids (adjusted OR 2.24, 95% CI 1.28–3.92) and pregestational hypothyroidism (adjusted OR 5.17, 95% CI 2.43–11.00), were significantly correlated with preeclampsia.

Conclusions: Mature ovarian teratoma, uterine fibroids and pregestational hypothyroidism may also contribute to the incidence of preeclampsia.

KEYWORDS:

• Preeclampsia
• pre-existing medical disorder
• risk factors
• case-control study

Details of Ethics Approval

This study was approved by the institutional review board of the Third Affiliated Hospital of Guangzhou Medical University. Reference number: NO. [2017]. Date of approval: 207 2017-03-24.

Disclosure statement

There is no conflict of interest.

Supplementary Material

Supplemental data for this article can be accessed here.

Additional information

Funding

This work was supported by the National Natural Science Foundation of China under Grant [81573262] and by the Fundamental Research Funds for the Central Universities under Grant [2016YXZD042].