Evaluation of obstetric outcomes and prognostic significance of graft function in kidney transplant recipient pregnancies

ABSTRACT

Objective

To evaluate obstetric and kidney outcomes in pregnancies with kidney transplantation.

Methods

We retrospectively reviewed 32 singleton pregnancies in kidney transplant recipients. Obstetric outcomes were explored according to the estimated glomerular filtration rates (eGFR) of patients.

Results

The incidences of fetal growth restriction, preeclampsia were 18.8% and 34.4%, respectively. There was a significant negative correlation between first-trimester eGFR and perinatal mortality (r = −0.546, p = .0.001) and composite adverse obstetric outcome (r = −0.415, p = .0.018).

Conclusion

The degree of transplanted kidney function impairment at the beginning of pregnancy is the major determinant of pregnancy outcome.

KEYWORDS:

• Kidney transplant
• pregnancy
• obstetric outcomes
• glomerular filtration rate

Disclosure statement

No potential conflict of interest was reported by the authors.

Statement of ethics

The study protocol was approved by the research institute’s committee on human research (52825153-604.01.01-72113)

Supplementary material

Supplemental data for this article can be accessed here.

Additional information

Funding

This study was not supported by any funders.