Gene polymorphisms of uric acid are associated with pre-eclampsia in South Africans of African ancestry

ABSTRACT

Objectives

To investigate the association of uric acid gene polymorphisms and Pre-eclampsia.

Methods

637 women of African ancestry [280 controls, 357 pre-eclampsia (early-onset = 187, late-onset = 170]) retrospectively. The rs505802, rs1212986, and rs1014290 SNPs were genotyped from purified DNA using real-time PCR.

Results

CT genotype (rs505802) was higher in pre-eclampsia [Adjusted p = 0.028*: OR (95% CI) = 1.73 (1.258–2.442)] and late-onset pre-eclampsia [Adjusted p = 0.027*: OR (95% CI) = 1.75 (1.165–2.2628)] than controls. CT genotype (rs1014290) was higher in early-onset pre-eclampsia [Adjusted p-value = 0.040*: OR (95% CI) = 1.60 (1.102–2.325)] than controls.

Conclusion

The genotyped rs505802 and rs1014290 are significantly associated with pre-eclampsia

KEYWORDS:

• Pre-eclampsia
• single nucleotide polymorphisms
• uric acid
• hyperuricemia

Acknowledgments

We would like to acknowledge the College of Health Sciences (CHS) for funding this project, the KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), with special thanks to Dr. Jennifer Giandari, Dr. Maryam Fish and Dr. Lavanya Singh for their assistance with DNA isolation. We would also like to acknowledge the Optics and Imaging Center, with special thanks to Miss Semone Thakoordeen for her support in this project. Lastly, we would like to thank the staff and colleagues of the Third Department of Internal Medicine, University of Fukui, Medical Sciences, Japan, especially Ms. Mami Shimizu and Emi Takeuchi.

Disclosure Statement

There are no conflicts of interest in this study.

Additional information

Funding

Dr. Veron Ramsuran is funded as a FLAIR Research Fellow (the Future Leader in African Independent Research [FLAIR] a partnership between the African Academy of Sciences [AAS] and the Royal Society that is funded by the UK Government as part of the Global Challenge Research Fund [GCRF]); supported by the South African Medical Research Council (SAMRC) with funds from the Department of Science and Technology (DST); and VR is also supported in part through the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE), a DELTAS Africa Initiative [grant # DEL-15-006] by the AAS.