Expression and role of ERAP1 in placental tissues of preeclampsia

ABSTRACT

Objective

This study aimed to investigate the expression and role of ERAP1 in preeclampsia pathogenesis.

Methods

ERAP1 expression of placental tissues was analyzed by Real-Time PCR and western blot. The location of ERAP1 was detected by immunohistochemistry. Cellular preeclampsia model was established by hypoxia treatment of HTR-8/SVneo cells (2% oxygen).

Results

The present study revealed that ERAP1 expression were significantly elevated in placental tissues of preeclampsia, and hypoxiaincreased ERAP1 expression in trophoblast, suggesting that ERAP-1 may be involved in the development of preeclampsia.

Conclusion

These finds highlight the role of ERAP1 in the pathogenesis of preeclampsia.

KEYWORDS:

• Preeclampsia
• ERAP1
• pathogenesi

Author contributions

Jianbo Wu conceived the project and designed the experiments. Yanyan Xu conducted experiments and wrote the manuscript. Junjiao Wu revised the manuscript.

Competing interests

The authors declare no competing financial interests.

Additional information

Funding

This study was funded by the Health and Family Planning Commission of Fujian [2016-ZQN-46].