ABSTRACT
Objective
The aim of this meta-analysis was to examine the association of ApoE polymorphism with the risk of developing PE.
Methods
A comprehensive search was carried out through PubMed, Scopus, and Embase. The ORs with corresponding 95% CIs were extracted. Fixed model was used for meta-analysis and in case of existing heterogeneity a random-effects model was applied.
Results
Association of ApoE polymorphism with the risk of developing PE was not statistically significant (OR = 0.86, 95% CI: 0.67–1.11; OR = 0.92, 95%CI: 0.73–1.15, respectively for ε2 and ε4).
Conclusion
ApoE polymorphism might not be associated with the risk of PE.
Author Contributions
Sakineh Shab-bidar and Morteza Abyadeh designed this study; Morteza Abyadeh and Fatemeh Heydarinejad extracted the data; Morteza Abyadeh and Maliheh khakpash performed the data analysis; Morteza Abyadeh and Yaser Asefi prepared the manuscript.
Disclosure statement
The authors report no conflict of interest.