Magnesium intoxication in women with preeclampsia with severe features treated with magnesium sulfate

ABSTRACT

Objective

To evaluate the maternal-neonatal outcome in magnesium (Mg)-intoxicated women with preeclampsia with severe features (PESF) treated with magnesium sulfate (MgSO₄).

Methods

A total of 19 Mg intoxicated PESF women (cases) were compared with 166 PESF women without signs of intoxication (controls).

Results

Mg serum levels of cases was higher compared to control group (12.36 ± 3.54 mg/dl versus 2.69 ± 0.83 mg/dl). 3 women died and 3 had major maternal morbidity in cases group compared with zero in the control group (P = 0.009). Mg intoxication was also significantly associated with perinatal deaths and low Apgar scores at 1 and 5 minutes.

Conclusion

Mg intoxication is associated with a increased risk of maternal and perinatal mortality and morbidity.

KEYWORDS:

• Magnesium intoxication
• hypermagnesemia
• magnesium sulfate
• preeclampsia with severe features

Acknowledgments

We thank Prof. Dr. Hendy Hendarto dr. SpOG(K) as the head of department who supported and gave permission to perform this study; we thank all staff in Department Obstetrics & Gynecology Faculty of Medicine Universitas Airlangga - RSUD Dr. Soetomo - RS Universitas Airlangga for their genuine support for this study; we thank our resident in training and the research team for their hard work in collecting data in this study; and we would like to thank all the patients who were involved in this study, without their participation the study could never be completed.

Disclosure statement

The authors declare no conflict of interest.