Association between intrahepatic cholestasis of pregnancy and risk of gestational diabetes and preeclampsia: a systematic review and meta-analysis

ABSTRACT

Objective

To investigate the association between intrahepatic cholestasis of pregnancy (ICP) and the risk of gestational diabetes mellitus (GDM) and preeclampsia via meta-analysis.

Methods

Pooled odds ratio (OR) and confidence interval (CI) of GDM and preeclampsia for women with ICP were calculated using the fixed- or random-effects model.

Results

Women with ICP were more likely to have GDM (pooled OR = 2.19, 95% CI: 1.58, 3.03, I² = 88.25%) and preeclampsia (pooled OR = 2.58, 95% CI: 2.37, 2.81, I² = 0%) than women without ICP.

Conclusion

The present study supports the concept that ICP is associated with the risk of GDM and preeclampsia.

KEYWORDS:

• Intrahepatic cholestasis of pregnancy
• gestational diabetes
• preeclampsia
• meta-analysis

Disclosure statement

Authors declare no conflict of interest.

Ethics Statement

the ethical approval is not required for this meta-analysis

Supplementary Material

Supplemental data for this article can be accessed here.

Additional information

Funding

None.