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ABSTRACT
Objectives
Evaluation of the association between fetal gender, serum beta-human chorionic gonadotropin, and serum testosterone, and preeclampsia.
Methods
Case-control study conducted at the Obstetrics and Gynecology Department. 120 patients divided into study group (patients with preeclampsia subdivided into mild and severe) and control group (normotensive women).
Interventions
Fetal gender was determined. Serum testosterone and HCG levels were estimated at 32 weeks or at the time of diagnosis of preeclampsia (study group) or recruitment (control group).
Results
Positive association between the male gender of the fetus and preeclampsia. Increased HCG and Testosterone were associated with developing preeclampsia.
Conclusion
The mechanism of preeclampsia could be androgen-mediated. There is a significant correlation between serum HCG and testosterone and preeclampsia.
Author’s participation
AM Elshahat: Protocol/project development
ZM Abolill: Protocol/project development, Data collection and management, manuscript writing/editing.
EA Kishk: Data collection and management, manuscript writing/editing.
OT Taha: Data analysis and management, manuscript writing/editing.
MS Elzamlout: Data collection and management, manuscript writing/editing.
Disclosure statement
No potential conflict of interest was reported by the authors.
Key message
The pathophysiology of preeclampsia is mysterious, but the role of the placenta is firmly documented. This study evaluated the role of fetal gender in the occurrence of preeclampsia and whether specific hormonal derangements exist (serum testosterone and serum beta HCG). Preeclampsia was more predominant in male bearing pregnancies than female bearing ones. We also reported increased serum testosterone as well as beta HCG in patients with preeclampsia.