Cystatin C as an indicator of renal damage in pre-eclampsia

ABSTRACT

Objective

To assess the predictive abilities of serum and urinary cystatin C levels for glomerular lesions in pregnant women with pre-eclampsia.

Methods

In this study, kidney function markers were compared between38 pregnant women with pre-eclampsia and 22 healthy pregnant women.

Results

The serum and urine levels of cystatin C and urea were significantly higher in the pre-eclampsia group than in the control group. Receiver operating characteristic curve analysis demonstrated that the serum cystatin C level (91.7%) had a superior diagnostic accuracy for pre-eclampsia than the other markers.

Conclusion

Serum cystatin C level maybe a significant marker of pre-eclampsia.

KEYWORDS:

• Serum cystatin C
• urine cystatin C
• pregnancy
• pre-eclampsia

Disclosure statement

No potential conflict of interest was reported by the authors.

Data availability statement

Data sharing is not applicable to this article as no new data were created or analyzed in this study.

Additional information

Funding

This work was funded by the Foundation for Research Support in the State of Minas Gerais (FAPEMIG-MG).