The comparison of side effects of methyldopa, amlodipine, and metoprolol in pregnant women with chronic hypertension

ABSTRACT

Objective

The aim of the study was to compare the complication of Antihypertensive drug; in pregnant women with chronic hypertension.

Method

This retrospective cohort study was performed on 300 pregnant women  with chronic hypertension. Results:  a relative risk of preeclampsia among methyldopa group was 3.45 times higher than the metoprolol, the relative risk of preterm labor was not significantly between methyldopa and metoprolol group, LBW, and IUGR in methyldopa and amlodipine groups .

Conclusion

Methyldopa and amlodipine are associated with the least side effects in pregnant women treated for chronic hypertension.the incidence of preeclampsia was greater in methyldopa group.

KEYWORDS:

• Pregnancy
• chronic hypertension
• metoprolol
• methyldopa
• adverse drug effects
• maternal outcomes
• fetal and neonatal outcomes

Acknowledgments

We would like to thank the following individuals who, in addition to members of our Editorial Board, will serve as referees for this series: Dwight P. Cruikshank, MD, Ronald S. Gibbs, MD, Gary D. V. Hankins, MD, Philip B. Mead, MD, Kenneth L. Noller, MD, Catherine Y. Spong, MD, and Edward E. Wallach, MD. 2We have invited select authorities to present background information on challenging clinical problems and practical information on diagnosis and treatment for use by practitioners.

Contributors’ Statement

Dr. Masoumeh Ghafarzadeh: conceptualized and designed the study, drafted the initial manuscript, and reviewed and revised the manuscript.

Dr. Amir Shakarami and Dr. Parsa Namdari: Designed the data collection instruments, collected data, carried out the initial analyses, and reviewed and revised the manuscript.

Dr. Fatemeh Yari: Coordinated and supervised data collection, and critically reviewed the manuscript for important intellectual content.

Disclosure statement

The authors deny any conflict of interest in any terms or by any means during the study. All the fees provided by research center fund and deployed accordingly.

Data availability statement

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.