ABSTRACT
Objective
Assess the efficacy and safety of carbetocin, versus oxytocin in the prevention of postpartum hemorrhage in hypertensive women.
Study design
A randomized clinical trial.
Setting
Obstetrics and Gynecology Department of Suez Canal University Hospital.
Patients
One hundred and sixty hypertensive pregnant women who underwent CS.
Interventions
Patients were randomized to receive either 10 IU oxytocin or 100 μg carbetocin. Primary outcomes included estimated blood loss, blood transfusion, hemoglobin (HB), and hematocrit changes pre- and post-delivery and the use of additional uterotonics.
Results
The postoperative HB was not different from preoperative HB in the carbetocin group (11.8 ± 1.2 vs. 11.2 ± 1.2 g/dL) while it decreased significantly in the oxytocin group (12.1 ± 3.8 vs. 10.4 ± 1.1 g/dL, p < 0.001). Blood loss was significantly more among the oxytocin group (679.5 ± 200.25 vs. 424.75 ± 182.59 ml) in the carbetocin group (p < 0.001). Nausea, vomiting, and sweating were reported more significantly in oxytocin group patients.
Conclusion
Carbetocin was more effective than oxytocin in reducing intraoperative and postoperative blood loss.
Author’s contribution
ZM. Ibrahim: Protocol/project development, Manuscript editing.
WA. Sayed Ahmed: Protocol/project development, manuscript writing/editing.
AM.Elbahie: Data analysis, manuscript editing
EM. Abd El-Hamid: Data collection and management, data analysis.
OT. Taha: Data collection and management, data analysis.
Key message
Carbetocin was more effective than oxytocin in reducing intraoperative and postoperative blood loss in cesarean section delivery, and both of them are safe with minimal tolerable side effects.
Disclosure statement
No potential conflict of interest was reported by the authors.