498
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Carbetocin versus oxytocin for prevention of postpartum hemorrhage in hypertensive women undergoing elective cesarean section

, , , &
Pages 319-325 | Received 18 Mar 2020, Accepted 07 May 2020, Published online: 18 May 2020
 

ABSTRACT

Objective

Assess the efficacy and safety of carbetocin, versus oxytocin in the prevention of postpartum hemorrhage in hypertensive women.

Study design

A randomized clinical trial.

Setting

Obstetrics and Gynecology Department of Suez Canal University Hospital.

Patients

One hundred and sixty hypertensive pregnant women who underwent CS.

Interventions

Patients were randomized to receive either 10 IU oxytocin or 100 μg carbetocin. Primary outcomes included estimated blood loss, blood transfusion, hemoglobin (HB), and hematocrit changes pre- and post-delivery and the use of additional uterotonics.

Results

The postoperative HB was not different from preoperative HB in the carbetocin group (11.8 ± 1.2 vs. 11.2 ± 1.2 g/dL) while it decreased significantly in the oxytocin group (12.1 ± 3.8 vs. 10.4 ± 1.1 g/dL, p < 0.001). Blood loss was significantly more among the oxytocin group (679.5 ± 200.25 vs. 424.75 ± 182.59 ml) in the carbetocin group (p < 0.001). Nausea, vomiting, and sweating were reported more significantly in oxytocin group patients.

Conclusion

Carbetocin was more effective than oxytocin in reducing intraoperative and postoperative blood loss.

Author’s contribution

ZM. Ibrahim: Protocol/project development, Manuscript editing.

WA. Sayed Ahmed: Protocol/project development, manuscript writing/editing.

AM.Elbahie: Data analysis, manuscript editing

EM. Abd El-Hamid: Data collection and management, data analysis.

OT. Taha: Data collection and management, data analysis.

Key message

Carbetocin was more effective than oxytocin in reducing intraoperative and postoperative blood loss in cesarean section delivery, and both of them are safe with minimal tolerable side effects.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Self-funded research

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access
  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart
* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.