Serum survivin is decreased in women with preeclampsia

ABSTRACT

Objective: To evaluate the serum survivin level in preeclampsia.

Methods: Eighty-eight pregnancies complicated with preeclampsia and 88 gestational-age (GA)-matched uncomplicated pregnancies were evaluated.

Results: Mean serum survivin was detected to be significantly decreased in the early- (EOPE) and late-onset (LOPE) preeclampsia subgroups than the GA-matched control-groups; and were comparable in EOPE- and LOPE-groups after correction for GA. Serum survivin had weak negative correlations with systolic and diastolic arterial blood pressure.

Conclusion: The serum survivin level was decreased in preeclamptic patients than the GA-matched controls. More comprehensive studies are needed to clarify the timing and extent of placental apoptosis in preeclampsia.

KEYWORDS:

• Survivin
• apoptosis
• early-onset preeclampsia
• late-onset preeclampsia
• hypertension

Acknowledgments

We would like to thank our beloved nurse Medine Eltutan from our pregnancy outpatient clinic in Istanbul Cerrahpasa University Hospital for her kind support and dedication during the patient recruitment.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Supplementary material

Supplemental data for this article can be accessed here.

Additional information

Funding

This study was financed by Istanbul Cerrahpasa University, Istanbul, Turkey, and Carl von Ossietzky University Oldenburg, University Hospital for Obstetrics and Gynecology in Klinikum Oldenburg AöR, Oldenburg, Germany.